Pd-catalyzed assembly of spirooxindole natural products: a short synthesis of horsfiline.

نویسندگان

  • Nina Deppermann
  • Heike Thomanek
  • Alexander H G P Prenzel
  • Wolfgang Maison
چکیده

The Pd-catalyzed intramolecular alpha-arylation of amides is applied to the synthesis of functionalized spirooxindoles. The substrate scope is evaluated, and the reaction is demonstrated to be useful for the assembly of spirooxindole natural products and derivatives thereof. As an application, a new synthesis of horsfiline 1 is presented, giving the natural product in only 4 steps from commercially available amino acid 12.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 75 17  شماره 

صفحات  -

تاریخ انتشار 2010